Investigation Of The Effects Of Trpc4 / 5 Inhibitor M084 In Experimental Alzheimer-Like Dementia Model

Purpose: This study aimed to research the effects of N-butyl-1H]-benzimidazole-2-amine (M084) on cognitive functions in an experimental Alzheimer-like dementia model. Materials and Methods: In our study, male rats were divided into five groups (n:8). The control (C) had 1 ml 0.9% saline solution administered intraperitoneally (i.p.) for 14 days. Scopolamine (S) was with first 7 days, followed by 3 mg/kg scopolamine days 8-14.Scopolamine+M084 (SM) i.p. dissolved 8-14 20 M084 10-14. (M) a single daily dose from 0-14. Positive (D) 5 donepezil administrations 0-14 8-14. On 15 passive avoidance, novel object recognition, modified elevated plus maze tests performed. Results: avoidance test, transfer latencies significantly lower group S compared C. passing time either closed arms 2nd-day test higher C D. recognition values C, SM, D, other S. Conclusion: conclusion, model, provided positive results visual memory; however, it ineffective memory types.